White's first appearance in a game show was on the June 20, 1980 episode of The Price Is Right, in which she was among the first four contestants. She did not make it onstage, but the clip of her running to Contestants' Row was rebroadcast as part of The Price Is Right 25th Anniversary Special in August 1996 and also was featured on the special broadcast Game Show Moments Gone Bananas. After Wheel of Fortune hostess Susan Stafford left in October 1982, White was chosen as one of three substitute hostesses (along with Vicki McCarty and Summer Bartholomew) to co-host the show. On December 13, 1982, White became the show's regular hostess and remained as the show's daytime hostess until 1991.
White's popularity peaked after the syndicated version of Wheel of Fortune made its debut in September 1983. Her 1987 autobiography, Vanna Speaks!, was a best-seller.[5] Also in 1987, she was featured in a Playboy pictorial, showing photos taken of her (before her career on Wheel of Fortune) wearing see-through lingerie.
In 1988[6], she appeared in the NBC television film Goddess of Love, in which she played Venus; fellow game-show personality Betsy Palmer co-starred as Juno. The film was panned universally by critics, with TV Guide joking that White's acting was "wheely" bad. Film historian Leonard Maltin added that said picture was "...bottom-of-the-barrel yet, on its own terms, a must-see."
White also has made cameo appearances on television shows such as The Super Mario Bros. Super Show!, 227, Simon and Simon, and Full House; and in films such as Naked Gun 33⅓: The Final Insult. She guest-starred on Married...With Children, in a gender-bending parody of the film Indecent Proposal; Vanna had the Robert Redford role, while Al Bundy was in Demi Moore's. She served as guest timekeeper for WrestleMania IV. In 1992, the Guinness Book of World Records recognized White as "television's most frequent clapper." On April 20, 2006, she was honored with a star on the Hollywood Walk of Fame.